Let's consider how taking Baralgin affects the human cardiovascular system: does it increase or decrease blood pressure, can it be taken with hypotension or hypertension?

Baralgin is a drug that has analgesic, antispasmodic and antipyretic effects. Available in the form of tablets for oral administration, solutions for injection (intramuscular / intravenous).

Composition and pharmacological properties

The active ingredient of the drug is metamizole sodium. The action is aimed at blocking cyclooxygenase enzymes, which are provocateurs of prostaglandin synthesis.

These properties provide:

• relief of inflammatory reactions;
• elimination of pain syndrome;
• normalization of thermoregulation of the body;
• reduction of puffiness.

The active substance Baralgin prevents the passage of pain impulses along the nerve fibers, provoking an increase in the threshold level of excitability of pain centers. Compared with others, the effect of this drug is moderate, it does not affect electrolyte metabolism. Baralgin renders by relaxing smooth muscle fibers.

In addition to metamizole sodium, the drug contains:

• pitofenone - has an antispasmodic property, belongs to the group of anticholinergics;
• fenpiverinium - blocks choline receptors, eliminating muscle spasms.

The drug is used for:

• fever
• weak / moderate pain syndrome of various etiologies (muscle, headache, toothache, joint pain).

The therapeutic effect is reached 10-15 minutes after taking the drug. The maximum effect of Baralgin is noted after 30-40 minutes. It is excreted from the body completely after 4-5 hours after ingestion, along with feces, urine.

Effect on pressure

Baralgin is able to lower blood pressure levels. This effect of the drug is due to its ability to relax the muscle fibers inside the vascular wall, followed by expansion of their lumen. Because of this, the process of blood circulation is facilitated, the pressure decreases. But this action does not last long, about 2-3 hours.

The level of blood pressure reduction depends on the amount of the drug taken per day. The hypotensive effect of Baralgin is more pronounced when taken parenterally. But you need to understand that it is not advisable to use a medicine to normalize pressure. The drug should be used only to eliminate the unpleasant symptoms that accompany hypertension (headache, spasms).

Mode of application

The standard regimen for taking Baralgin is 1-2 tablets 2 times / day. Drink the remedy, regardless of meals, washed down with plain water. When administered by injection, the maximum daily dosage is 10 ml. Before making an injection, the medication is heated to the temperature of the human body in order to prevent the occurrence of an infiltrate at the injection site. Treatment with the drug is carried out for 5 days. Prolongation of therapy is possible only with the permission of the doctor.

Adverse reactions

The use of Baralgin can provoke the occurrence of the following adverse reactions:

• anaphylactic shock;
• rashes like urticaria;
• inflammation of the conjunctiva;
• angioedema;
• malignant exudative erythema;
• toxic epidermal necrolysis;
• bronchospastic syndrome;
• changes in blood parameters (decrease in the level of erythrocytes, leukocytes)
• violation of the functionality of the kidneys;
• urinary incontinence;
• change in the amount of urine excreted (decrease / increase);
• acute interstitial nephritis;
• change in the color of urine (it becomes red);
• lowering blood pressure;
• violation of the heart rhythm.

Given the presence of a large list of adverse reactions, it is recommended to take the drug only with the permission of the attending physician. If various disorders are observed during therapy, the drug is withdrawn.

Contraindications

Baralgin is contraindicated in:

• hepatic porphyria;
• congenital deficiency of glucose-6-phosphate dehydrogenase;
• bronchial asthma;
• pregnancy (1st and 3rd trimester);
• pathologies accompanied by bronchospasm;
• anaphylactoid reactions in response to NSAIDs, the active components of which are ibuprofen, paracetamol, naproxen;
• severe disorders of the liver / kidneys;
• blood pathology;
• hypersensitivity to components.

In conclusion, it must be said that Baralgin is an analgesic and antipyretic drug. Despite the fact that it is able to reduce pressure, it is not advisable to use the medicine for the treatment of hypertension, since the hypotensive effect is weak and does not last long. And frequent intake of tablets in excess of daily dosages can lead to a sharp deterioration in well-being.

Last updated: October 19, 2019

Doctors prescribe the pharmaceutical drug "Baralgin" for high blood pressure, when the patient complains of a severe headache. This non-narcotic analgesic medication is designed to relieve pain, normalize body temperature and eliminate inflammatory foci. But it should be used with extreme caution for problems with pressure, since even the slightest errors in dosage can excessively reduce blood pressure.

Form and composition

"Baralgin" - a combined drug from the NSAID group, consisting immediately of 3 active components - pitofenone hydrochloride, metamizole sodium and fenpiverinium bromide, has the following dosage forms:

• pills;
• candles;
• injection.

The drug in question belongs to the group of non-steroidal anti-inflammatory drugs and has a wide spectrum of action, the main of which is an anesthetic. "Baralgin" blocks the enzymes involved in the synthesis of prostanoids, as a result of which the muscles relax, and an analgesic effect occurs. It has an antipyretic, weak anti-inflammatory and antispasmodic effect.

Indications and contraindications

The medicine will help relieve muscle spasm.

"Baralgin" helps relieve pain of varying intensity and etiology, stop spasms in the muscles and uterus in patients with algomenorrhea. In addition, it is advisable to take the medicine as a symptomatic treatment of an acute form of urolithiasis, renal and hepatic colic, as well as biliary dyskinesia. The drug is often prescribed to patients who have undergone surgery, patients with neuralgia and artroid pain. As an additional drug, "Baralgin" has proven itself well for aching bones, high fever and a feverish state.

The relevance of the use of "Baralgin" for a particular case should be determined by the profile doctor individually for each patient.

The instructions for use describe the following cases when taking Baralgin will adversely affect health:

• hypersensitivity to the components of the medication;
• reduced concentration of hemoglobin in the blood;
• impaired functioning of the myocardium, kidneys and liver;
• increase in heart rate;
• prostate hypertrophy.

In addition, the drug is harmful to children under 3 years of age, women during pregnancy in the initial stages and during breastfeeding. It is strictly contraindicated to use the drug in patients who have been diagnosed with angle-closure glaucoma and intestinal obstruction, which consists in the introduction of one segment of the intestine into the lumen of another.

Is it possible with high blood pressure?

The most important thing in the presence of pressure is to choose the right dosage of the drug.

"Baralgin" at the correct dose does not increase or decrease blood pressure, so people who suffer from jumps in blood pressure can safely use it against headaches. But if you abuse this medicine, then the patient is threatened with an increase in heart rate and a sharp decrease in blood pressure. In addition, taking the medication can rapidly lower the body temperature and provoke chills.

How to use?

"Baralgin" has the ability to quickly be absorbed by the walls of the stomach and decompose in the liver. Remains of medicinal substances leave the body with urine through the body within 3 hours. You can drink tablets no more than 5 days in a row, in a dosage of 1-2 pcs. in a day. At the discretion of the attending physician, the treatment regimen can be adjusted.

Adverse events

One of the most dangerous side effects when using Baralgin is a rapid drop in blood pressure. Usually this phenomenon occurs due to taking the drug in high doses or with the rapid introduction of the solution. Low blood pressure is dangerous with loss of consciousness and the development of collapse. It happens that arterial hypotension against the background of the use of "Baralgin" occurs at a high body temperature in a patient.

Additionally, the drug under consideration can provoke other side effects, including:

A sore throat can be a side effect of taking the drug.

• irritation, itching of the skin;
• hives;
• dry mucous membranes;
• vaginitis;
• angioedema;
• anaphylactic shock;
• stomatitis;
• feverish state;
• sore throat;
• deterioration in kidney function;
• nephritis;
• arrhythmia, tachycardia.

2 Can children and pregnant women use it?

3 What is harmful: side effects

Often people are interested in the question: is it possible to use "Baralgin" with high blood pressure? Since the drug has an analgesic effect, it can be added to the list of drugs for headaches with high blood pressure. With a moderate and correct dosage, the drug does not affect the level of blood pressure. However, when consumed in excess, it increases heart rate and lowers blood pressure.

What is "Baralgin"?

"Baralgin" belongs to the group of non-steroidal anti-inflammatory drugs with multidirectional action. It blocks cyclooxygenase enzymes, which leads to muscle relaxation. This contributes to the analgesic effect. It is also used as an antipyretic. The main component of the drug - metamizole sodium (non-narcotic analgesic, antipyretic agent) has weak anti-inflammatory properties that contribute to the retention of water and sodium in the body. This contributes to a slight effect of the drug on the mucosa of the gastrointestinal tract.

"Baralgin" is produced in the form of tablets for internal use, and in ampoules for intramuscular and intravenous injections. The package consists of 5 ampoules or 20 tablets, which include:

The drug is rapidly absorbed in the stomach and decomposed in the liver. Most of the active substance is absorbed into the blood proteins. The remains are excreted in the form of urine, passing through the kidneys for 3 hours. "Baralgin" can be taken no more than 5 days in a row, 1-2 tablets per day. Alcohol does not affect the action of the drug.

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Indications for the use of "Baralgin" under pressure

The drug helps to relieve acute attacks of pain of a different nature.

The drug is prescribed to the patient after a preliminary medical examination, if he has:

• acute attacks of pain (migraine, toothache, pain syndrome after surgery);
• spasms of smooth muscles (gastric, hepatic and intestinal colic, biliary dyskinesia, bladder tenesmus);
• inflammatory processes accompanied by fever.

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Contraindications

• individual allergic reactions to the components of the drug;
• poor kidney or liver function;
• deficiency of glucose-6-phosphate dehydrogenase;
• bronchial asthma;
• problems with blood formation (agranulocytosis);
• heart rhythm disturbances;
• prostatitis;
• low blood pressure;
• intestinal obstruction.

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Can it be used by children and pregnant women?

"Baralgin" is harmful to children under 15 years of age. In very severe cases, it is possible to prescribe specific doses of the drug in the form of tablets to children over 6 years of age. The drug is also contraindicated for pregnant women, especially in the first (1–12 weeks) and third (from the 28th week until delivery) trimesters of pregnancy. In critical situations, it can be used in the second trimester under the strict supervision of a doctor. Metamizole passes into breast milk, therefore it is not advisable to use the medicine during lactation, or you need to stop breastfeeding for 2 days after taking it.

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What is harmful: side effects

When used correctly, most often "Baralgin" does not cause any side effects.

But despite the safety of the reception, exceptions occur: failures of the cardiovascular (a sharp drop in blood pressure), hematopoietic (thrombocytopenia, leukopenia), excretory (impaired functioning of the kidneys) systems, allergic reactions (bronchospasm, rash, anaphylactic shock). Sometimes there is vomiting, dry mouth, dizziness, convulsions, abdominal pain, constipation, shortness of breath and drowsiness. Most often this is due to an overdose or prolonged use of the drug. In this case, you need to clean the stomach, take the sorbent and stop using Baralgin.

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Algorithm for measuring blood pressure with devices of various types

Normal indicators and causes of changes

What do the numbers mean when measuring blood pressure? The upper (systolic) is related to how actively the heart ejects blood into the aorta, and the lower (diastolic) characterizes vascular tone.

BP classification table

Sometimes blood pressure changes disproportionately:

Rules for preparation and methods of conducting according to the standard

In order to take measurements, you must purchase an electronic or mechanical tonometer.

The mechanical version consists of:

• cuffs with a rubber pear for pumping air and a pressure gauge showing the strength of blood pressure;
• a stethoscope for listening to heart sounds;

Electronic semi-automatic is a cuff with an attached rubber bulb and a box with a display showing the results.

Electronic automatic - a cuff with the attached box with the display.

Find out which blood pressure monitor to choose for home use from the following article.

Many factors can distort the results, so if the case is not emergency, you need to prepare for measurements in advance:

• the results are distorted after drinking alcohol, a cup of coffee or a bath;
• if you feel chills, you first need to warm up;
• you should not smoke for at least half an hour before the procedure - this leads to vasoconstriction;
• after physical activity, it is better to wait 1-2 hours - the results may be underestimated;
• after eating, you need to wait 1-2 hours - the results will be overestimated;
• an overfilled bladder increases intra-abdominal pressure and, as a result, arterial pressure;
• sleep deprivation and constipation also skew the results.

In the case of measurements on the upper arm, the cuff is put on 2 cm above the bend of the elbow. It is selected according to size and fastened so that it does not overtighten the hand. When measuring with a mechanical device, random movements of the hand do not distort the result, but when using an electronic device, the hand must be motionless.

On which arm is it correct to measure blood pressure? For starters, both. And after that they are guided by the highest indicators (often blood pressure is different on different hands). If the higher pressure was on the left, then the left hand is checked in the future, and vice versa.

For more information on preparing for the blood pressure measurement technique, see the video:

Step-by-step technique for using a mechanical tonometer

When using a mechanical device, it is necessary to clamp the brachial artery with the help of an inflated cuff and use a stethoscope to listen to the heart tone while bleeding air. Measurements are taken while sitting with obligatory support for the back:

1. Relax. Never cross your legs. Rest calmly for 5 minutes, only then begin the procedure.
2. The arm is placed on the table so that the cuff is at the level of the heart. If measurements are taken lying down, raise your arm so that the cuff is located at the level of the middle of the chest. The support should be under the entire arm so that it does not hang down. If you raise your cuffed arm above the level of the heart, then the result is underestimated and vice versa.
3. Attach the phonendoscope to the pulsation point in the bend of the elbow so that it does not touch the tube or cuff.
4. With a rubber bulb, quickly inflate air to 30–40 mm Hg. Art. above the level when the ripple disappears.
5. After that, start bleeding no faster than 2 mm Hg. Art. for one pulse beat, following the arrow on the manometer. There will come a moment when the blood, driven by heart contractions, hitting the walls of the narrowed vessel with force, will be able to break through the weakening obstacle. It is these beats that will be heard through the stethoscope.
6. By registering the appearance of the first blow and the number on the pressure gauge, we get the first indicator (upper).
7. Listening further, note the moment the tones disappear - this will be the second indicator (lower).

To more accurately understand the algorithm of actions for the correct measurement of blood pressure in the peripheral arteries, this video will help:

How to properly measure with an electronic device

The initial actions correspond to the use of a mechanical device: sit down, rest for 5 minutes, put on the cuff and start the measurement. Further actions are facilitated by the fact that electronic devices do not require the use of a stethoscope:

• for a semi-automatic device, manually inflate air, the device will perform all further actions itself - it relieves pressure and displays the received data;
• the automatic device will do everything by itself - it pumps, bleeds, measures and shows the result.

The device for the wrist is fastened to the top with a display, which is located approximately 1 cm above the hand. Then put the palm of this hand on the opposite shoulder so that the device is located at the level of the heart, press the start button with your free hand and grab the arm with the tonometer under the elbow with it to fix it more rigidly, since it is better not to move during the measurement.

self help

This video tells you what manipulations are needed to measure blood pressure by a mechanical method to yourself if no one is around:

And now we will tell you what to do with an increase or decrease in blood pressure.

With an increase

If in the morning you feel unwell and your blood pressure is slightly elevated, you can influence it by changing your daily diet. Arrange a rice-compote day for yourself by boiling rice without salt and preparing dried fruit compote without sugar.

When the blood pressure has risen sharply, the person must be laid with the upper body raised, the lights dimmed, a heating pad applied to the legs, and a towel moistened with cool water to the head.

If you can’t lie down, sit down, leaning back in a chair or armchair, lower your legs.

With increased emotionality, take 40–50 drops of Corvalol, you can put a captopril tablet under the tongue. The next pressure control should be carried out not earlier than in an hour.

Do not try to reduce the performance by more than 20% of the initial level - sharp fluctuations cause brain complications.

Downgrading

• A cup of sweet coffee will bring quick but short-term relief. Strong sweet tea acts more slowly, but gives a more lasting result. To enhance the effect, you can add a spoonful of cognac to tea.
• Half a teaspoon of honey, eaten with a pinch of cinnamon, will help to cheer up a little. If a stronger effect is needed, then 1/4 tsp is brewed in a glass of boiling water. cinnamon, cool slightly and dissolve a couple of teaspoons of honey in a very warm infusion.
• Take 35 drops of pharmaceutical alcohol tincture of ginseng, eleutherococcus or magnolia vine.

A person can often help himself by getting rid of factors that worsen the condition and tone of blood vessels:

• each kilogram of weight gain increases the upper pressure by 1-2 units;
• nicotine causes vasoconstriction and increases blood pressure;
• a constant excess of salt in the diet leads to a stable fluid retention, which increases pressure, entering the vascular bed;
• ethyl alcohol causes an imbalance in vascular tone.

Knowing the algorithm for measuring blood pressure, you can easily use both a mechanical and an electronic tonometer. Such knowledge and the presence of the device at hand will help to identify the causes of poor health (migraine, weakness, nausea) and seek help in time.

We offer the most important on the topic: "baralgin increases blood pressure" with comments from professional doctors. We have tried to describe all the problems in accessible words. If something is not clear or you have questions, then you can leave them in a special field after the article.

Doctors prescribe the pharmaceutical drug "Baralgin" for high blood pressure, when the patient complains of a severe headache. This non-narcotic analgesic medication is designed to relieve pain, normalize body temperature and eliminate inflammatory foci. But it should be used with extreme caution for problems with pressure, since even the slightest errors in dosage can excessively reduce blood pressure.

"Baralgin" - a combined drug from the NSAID group, consisting immediately of 3 active components - pitofenone hydrochloride, metamizole sodium and fenpiverinium bromide, has the following dosage forms:

The drug in question belongs to the group of non-steroidal anti-inflammatory drugs and has a wide spectrum of action, the main of which is an anesthetic. "Baralgin" blocks the enzymes involved in the synthesis of prostanoids, as a result of which the muscles relax, and an analgesic effect occurs. It has an antipyretic, weak anti-inflammatory and antispasmodic effect.

"Baralgin" helps relieve pain of varying intensity and etiology, stop spasms in the muscles and uterus in patients with algomenorrhea. In addition, it is advisable to take the medicine as a symptomatic treatment of an acute form of urolithiasis, renal and hepatic colic, as well as biliary dyskinesia. The drug is often prescribed to patients who have undergone surgery, patients with neuralgia and artroid pain. As an additional drug, "Baralgin" has proven itself well for aching bones, high fever and a feverish state.

The relevance of the use of "Baralgin" for a particular case should be determined by the profile doctor individually for each patient.

The instructions for use describe the following cases when taking Baralgin will adversely affect health:

• hypersensitivity to the components of the medication;
• reduced concentration of hemoglobin in the blood;
• impaired functioning of the myocardium, kidneys and liver;
• increase in heart rate;
• prostate hypertrophy.

In addition, the drug is harmful to children under 3 years of age, women during pregnancy in the initial stages and during breastfeeding. It is strictly contraindicated to use the drug in patients who have been diagnosed with angle-closure glaucoma and intestinal obstruction, which consists in the introduction of one segment of the intestine into the lumen of another.

"Baralgin" at the correct dose does not increase or decrease blood pressure, so people who suffer from jumps in blood pressure can safely use it against headaches. But if you abuse this medicine, then the patient is threatened with an increase in heart rate and a sharp decrease in blood pressure. In addition, taking the medication can rapidly lower the body temperature and provoke chills.

"Baralgin" has the ability to quickly be absorbed by the walls of the stomach and decompose in the liver. Remains of medicinal substances leave the body with urine through the body within 3 hours. You can drink tablets no more than 5 days in a row, in a dosage of 1-2 pcs. in a day. At the discretion of the attending physician, the treatment regimen can be adjusted.

One of the most dangerous side effects when using Baralgin is a rapid drop in blood pressure. Usually this phenomenon occurs due to taking the drug in high doses or with the rapid introduction of the solution. Low blood pressure is dangerous with loss of consciousness and the development of collapse. It happens that arterial hypotension against the background of the use of "Baralgin" occurs at a high body temperature in a patient.

Additionally, the drug under consideration can provoke other side effects, including:

A sore throat can be a side effect of taking the drug.

• irritation, itching of the skin;
• hives;
• dry mucous membranes;
• vaginitis;
• angioedema;
• anaphylactic shock;
• stomatitis;
• feverish state;
• sore throat;
• deterioration in kidney function;
• nephritis;
• arrhythmia, tachycardia.

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The following drugs have a similar composition and principle of action to Baralgin:

A drug of the NSAID group is dispensed only by prescription from a doctor. It should be stored in the original packaging as far away from children as possible, in a dry and out of direct sunlight place. The air temperature in the room where Baralgin is stored should not rise above 24 degrees Celsius. Shelf life - 3 years. After the expiration of the date indicated on the package, the medicinal product is not subject to use, it is disposed of.

Baralgin is an effective combined pain reliever.

This drug is often taken by people with hypertension to relieve headaches.

Before use, you need to know how baralgin affects pressure so as not to harm your body.

Letters from our readers

My grandmother's hypertension is hereditary - most likely, the same problems await me with age.

I accidentally found an article on the Internet that literally saved my granny. She suffered from headaches and had a second crisis. I bought a course and checked the correct treatment.

Some non-narcotic analgesics - Baralgin M. medicines, which are preserved in the free sale and the state register of drugs that are included in the standard for emergency medical care, include the properties, mechanism of action and indications of Baralgin in detail instructions for use.

Many diseases are accompanied by pain sensations of varying intensity, inflammation, muscle spasms, fever, so the topic of choosing the right drug that alleviates the patient's condition is always relevant. For these purposes, in the arsenal of doctors today there are many effective and safe drugs, incl. the latest developments are non-steroidal anti-inflammatory drugs belonging to the class of selective inhibitors. These drugs gradually replaced pyrazolone drugs, which were previously popular and actively used for the relief of acute pain and fever, from the pharmaceutical market. Baralgin is one of them.

Pharmacological properties of the drug

Under the trade name, in which the word Baralgin is present, only one drug is registered in Russia - Baralgin M, containing a single active substance. This is metamizole sodium, otherwise analgin, a derivative of 5-pyrazolone. Baralgin M is classified as an NSAID with mild anti-inflammatory activity, non-selectively blocking cyclooxygenase enzymes and inhibiting the synthesis of prostaglandins. Until 2009, there was a drug called "Baralgin", the composition of which included 3 active ingredients. In addition to metamizole, these are myotropic antispasmodic pitofenone and m-anticholinergic fenpiverinium bromide. The combination of these active compounds led to a wider range of drug use.

Why Baralgin was prescribed: in addition to the therapeutic effect of metamizole sodium, it could also be used to relax the smooth muscles of internal organs and vascular walls, relieve spastic pain, strengthen spasmodic muscle fibers of blood vessels, improve blood flow, incl. cerebral, and to lower blood pressure.

At the moment, pharmacy chains do not sell the combined drug.

Baralgin M, made on the basis of metamizol, has the following effect:

• analgesic- weakens or completely relieves pain of low or moderate intensity due to inhibition of the conduction of pain impulses, an increase in the threshold of excitability and a decrease in the sensitivity of receptors to the action of various pain stimuli;
• antipyretic- reduces pathologically elevated temperature without affecting the normal value. The effect is achieved by the inhibitory action of Baralgin, which reduces the flow of impulses from thermal receptors to the nuclei of the hypothalamus, which are responsible for thermoregulation. Due to the suppression of the activity of the nerve cells of the posterior hypothalamus, there is a decrease in heat production, the elimination of peripheral vasoconstriction, an increase in heat transfer and, accordingly, the return of body temperature to normal;
• antispasmodic- eliminates spasms caused by a strong contraction of the muscles of the walls of the internal organ, mainly the ureters, renal pelvis, bladder wall of the urinary cavity and bile ducts;
• anti-inflammatory- reduces the severity of inflammation. Minor force effect.

Composition, release forms

The holder of the registration certificate Baralgin M is the global pharmaceutical corporation Sanofi-Aventis. The drug is produced in India. It is produced in 2 states, corresponding to the method of administration into the body and achieving the desired therapeutic effect: in a dosed tablet dosage form and in ampoules containing a solution for slow intravenous infusion or intramuscular injection. The dosage of the active substance in them is the same - 500 mg of metamizole sodium (analgin) in a tablet and in a ml of solution.

The instruction gives a description of the appearance and composition of Baralgin:

• Pills- white, round, without bulges, with a rounded side surface. On one side of the tablet, a separating risk is applied in the middle, on the other, the inscription BARALGIN-M is engraved. The tablets are packaged in a 10 cell green plastic blister. 1, 2, 5 or 10 such blister packs can be enclosed in an individual cardboard pack with instructions. As auxiliary ingredients, the composition includes polyethylene glycol 4000 (macrogol) - a filler, a binder and magnesium stearate - a lubricant.
• injection solution- a transparent, almost colorless liquid, poured into dark glass ampoules with a capacity of 5 ml. Plastic contour pallets (for 5 ampoules) together with the instructions are placed in cardboard boxes. The solvent is specially purified water for injection.

How Baralgin M works

The clinical and pharmacological classifier refers Baralgin M to the group of antipyretic analgesics - this is the main purpose of the drug. Drugs containing metamizole are banned in many countries due to their potential to cause agranulocytosis even with a single dose. This is a life-threatening pathological condition characterized by a decrease in the number of white blood cells, which makes a person susceptible to various fungal and bacterial infections.

But, unlike many NSAIDs with a pronounced anti-inflammatory effect, Baralgin does not disrupt sodium metabolism in the body, does not retain water, does not lead to edema, and does not irritate the gastrointestinal mucosa. Only the attending physician can assess the risk-benefit ratio in each case.

What helps Baralgin M:

• the strongest analgesic - effectively fights pain of various origins, incl. localized in the nerve trunks, muscles, tendons, tooth area, any part of the head;
• reduces fever - the strength of action is inferior to the antipyretic effect of Aspirin (not recommended for the treatment of fever in children and adolescents due to the likelihood of developing Reye's syndrome), but surpasses the effect of paracetamol and Ibuprofen;
• relieves spasm, lowering the tone of the smooth muscles of the hollow organs - the bile duct, ureters, bladder, and other organs of the urinary system.

The action of the tablets manifests itself already 20-40 minutes after oral administration, the maximum effect occurs after 4 hours. To quickly alleviate the condition, reduce pain, hyperthermic syndrome, Baralgin M is administered intramuscularly (in a medical institution under the supervision of medical staff - intravenously). When prescribing a drug and choosing a dosing regimen, the processes that occur with the active substance after its introduction into the body are taken into account.

Pharmacokinetic parameters of clinical significance are given in the instructions:

• Suction: tablets are almost completely absorbed from the gastrointestinal tract, in the intestinal walls the active substance undergoes hydrolysis - it is completely decomposed by water, forming an active metabolite. Baralgin does not enter the blood unchanged, only after intravenous injection metamizole is found in plasma in small quantities. Plasma concentration of the metabolite sufficient to provide a therapeutic effect is fixed after 20-30 minutes, peak values ​​are reached after 2 hours.
• Distribution: 50-60% of the resulting metabolite in the systemic circulation circulates in a bound state in the form of a complex with plasma proteins. Widely distributed, excreted in breast milk in doses that can cause a therapeutic effect.
• Metabolism: under the influence of hepatic enzymes, the metamizole sodium metabolite is transformed into another form of the pharmacologically active metabolite and into several inactive compounds.
• Excretion: metabolites leave the body mainly with urine (more than 96%). The concentration of the substance is halved 14 minutes after parenteral (intravenous) administration and 2.7 hours after taking the tablet. In patients with cirrhosis of the liver, the half-life increases by 3 times and can reach 10 hours, which increases the toxicity of Baralgin, so this category of patients requires dose adjustment downwards.

Indications for admission

The use of Baralgin is justified in cases where there are no adequate substitutes or their insufficient effectiveness. It is usually prescribed as part of complex therapy. It is unacceptable to use the drug for the treatment of acute pain in the abdomen until the type and exact cause of this pain syndrome is identified.

Indications for use Baralgin such:

• febrile syndrome caused by infection, inflammatory process, insect bite, consequences of transfusion or its complication;
• pain of varying severity, localization and etiology, incl. resistant (resistant) to another treatment:
• joint, muscle, dental, menstrual or headaches;
• decompression sickness, burn injuries, postoperative recovery period, post-traumatic pain;
• various types of myositis, orchitis, neurological pathologies, sciatica;
• weak cramping pains or spasms of moderate strength - intestinal, biliary, renal colic.

Instructions for use

When determining the dose, method of administration and prescribing the regimen, the patient's condition, age, body weight, type of disease and the severity of the pain syndrome are taken into account. Adhere to the rules of the minimum effective dosage with the shortest duration of the course.

As an analgesic and antipyretic agent, Baralgin M is allowed to be taken at elevated pressure, in a moderate dose and with the correct administration of the injection solution, the pressure level does not change.

However, when using a high dose (more than 1 g of metamizole) or too fast (faster than 1 ml / min) intravenous infusion, an increase in heart rate and a decrease in blood pressure up to a rapid fall and shock are possible. Therefore, it is permissible to increase the dose and timing of admission only with the permission of the attending physician, and it is desirable to administer Baralgin in a hospital setting or under the supervision of an experienced specialist.

• Tablets should be taken with or without food, consumed as a whole with a sufficient amount of liquid. Before direct introduction into the body, ampoules with Baralgin should be warmed to normal body temperature. For intramuscular injection, it is better to use a long thin needle.
• A single dose for patients older than 15 years - 500 mg, in exceptional cases - 1000 mg. Multiplicity of reception: 2-3 times, but not more than 3 g (6 pcs.) per day in the form of tablets and 2 g (4 ml) - solution.
• Newborns aged 3-12 months (5-9 kg) - only intramuscular use (0.1-0.2 ml). Children 1 year and older - 50-100 mg (as a solution) for every 10 kg of weight.
• The duration of use is limited to 5 days - as an analgesic, 3 - as an antipyretic.

An overdose is manifested by dyspeptic disorders, a decrease in the amount of urine, a pathological decrease in pressure or temperature, shortness of breath, convulsions, bleeding, a change in consciousness, renal, hepatic or respiratory failure. In this case, urgent gastric lavage is required - vomiting, the use of a probe, laxatives or enterosorbents.

With late detection of acute symptoms of poisoning, methods are shown that contribute to a sharp increase in diuresis, various blood purification procedures, Diazepam, and fast-acting barbiturates.

Increased caution requires the use of the drug by patients with hypotension, high fever, renal, hepatic, cardiac dysfunction, persons abusing products containing ethyl alcohol.

It is permissible to use Baralgin M during pregnancy only in the 2nd trimester, and only as directed and under the supervision of a physician. In the 1st, 3rd trimester and during breastfeeding (if less than 48 hours have passed after ingestion), the instruction prohibits taking Baralgin.

In addition to these, there are other contraindications:

• intolerance to drug components, pyrazolidins, any pyrazolone derivative, allergic reaction to analgesics;
• violations of hematopoietic processes, diseases of the blood system;
• congenital deficiency of G-6-FDG enzyme activity;
• acute phase of hepatic porphyrin disease.

Side effects

The use of Baralgin is often accompanied by various adverse events. The risk increases if the established dosages and identified contraindications are not observed, which are reported by the instructions.

The manufacturer warns about the possibility of developing the following effects:

• acute coronary allergic syndrome, a sharp drop in pressure, cardiac arrhythmia;
• malfunctions of the kidneys, acute inflammation of the interstitial tissue, red staining of urine;
• changes in the blood picture, hematological disorders of immune genesis, up to the insufficiency of all types of blood cells and death;
• urticaria, bronchospasm, hypersensitivity reaction, anaphylaxis, fixed drug rash or erythema, itching, burning, edema;
• post-injection infiltrate - painful induration at the injection site.

The instruction informs about the numerous drug interactions of Baralgin. In order to prevent an increase in the toxicity of drugs and an increase in the severity of negative consequences, it is necessary to notify the doctor about all cases of simultaneous or sequential use of other medications. Only a specialist will exclude unacceptable combinations and adjust the dosages of drugs.

The cost of the drug, analogues

Baralgin is a prescription drug. It should be stored in its original container at a temperature in the range of 8-25 degrees. The medication is valid for 4 years. How much Baralgin M costs is affected by the location of the pharmacy and the pricing policy of the pharmacy chain.

The average cost is:

• tablets 500 mg 10 pcs. - 100 rubles, 20 pcs. - 210 rubles, 100 pcs. - 940 rubles;
• ampoules with a solution of 5 ml 500 mg / ml 5 pcs. - 310 rubles.

There are many substitutes with a similar therapeutic effect, also based on metamizole sodium, primarily Analgin, Optalgin, Metamizole sodium, suppositories for children Spazdolzin.

Full, structural substitutes for the combined preparation Baralgin, including 3 active substances, are the following analogues in tablets:

• took;
• Spazgan;
• Revalgin;
• Spasmaton;
• Maxigan;
• Spasmoblock.

Analogues in the form of a / m solution:

• Spazmalgon;
• Spasmofarm;
• Spasmalin.

Taking Baralgin or its analogues is fraught with the development of serious adverse reactions, their uncontrolled use can be life-threatening, therefore, the treatment and choice of the drug must be approached with full responsibility. The final decision is best left to a professional.